By Th. Büchner (auth.), W. Hinterberger, A. J. Barrett, K. Lechner, E. Deutsch (eds.)
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Extra info for 11th Annual meeting of the EBMT: European Cooperative Group for Bone Marrow Transplantation
Smith JW,. : Marrow transplantation for acute nonlymphocytic leukemia in first remission using fractionated or single-dose irradiation. Phys. 8: 817, 1982 4. : Successful allogeneic bone marrow transplantation with the same donor after graft rejection: application of a modified conditioning regimen. Blut 39: 47, 1979 Exp. Hematol. (suppl. 17) 13:33 (1985) © International Society for Experimental Hematology Evaluation of Cyclophosphamide and Different TBI Regimens (Single Dose or Fractionnated) in Allogeneic Marrow Transplantation for Hematologic Malignancies D.
She received six montly 4-day courses of high-dose melphalan and prednisone (MP), as described elsewhere ( 1), until remission occurred. Remission Iasted unmaintained for 9 months, after which the disease relapsed. Cyclic MP were resumcd and again induced a marked decrease in tumour mass. e. 5 months after the relapse, BMT was performed from the patient's HLA-identical, MLC-negative, sister. 8 g/dl) and about 10°/o monoclonal plasma cells in the bone marrow. Skeletal x-ray survey was negative for osteolytic lesions.
The all 11 remain in complete remission, 2 at 20 months + after graft (median 13 months). The median of interval between CR and ABMT is 5 months. We conclude : 1) The wide range of stem cells sensitivity to Asta Z justify the predetermination of the optimal dose of drug for each individual patient. 2) ABMT can successfully be done with pretreated marrow containing 5 + 5% CFUc. 3) Delayed kinetics Öf recovery of platelets are observed in ANLL. 4) ABMT in poor risk acute leukemia of adults is not associated with a high rate of lang term unmaintained CR.