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Extra info for 236th ACS National Meeting
Tugasheva2, K. Holloway3, and G. McGaughey3. (1) Department of Medicinal Chemistry, Merck Research Laboratories, West Point, PA 19486, (2) Department of Biological Chemistry, Merck Research Laboratories, West Point, PA 19486, (3) Molecular Systems, Merck Research laboratory Alzheimer's disease (AD) is now the most common neurodegenerative condition, causing much financial and emotional burden in terms of caring for affected patients. The deposition of amyloid ≤]peptide(A≤]) in the brain is one of the characteristics of AD pathogenesis.
This poster will illustrate the extensive exploration of the pyridine region of the molecule and a variety of synthetic strategies that were developed, including the installation of halides through the pyridodiazonium ion species and various functional groups. Also, a ring expansion reaction of the 4-piperidone as a versatile route to regiospecific syntheses of various functionalities for pyridoazepine analogs will be described. MEDI 55 Synthesis and metabolism of a potent 5HT1B antagonist Charles S.
N. com, and Shoichi Fukayama4. (1) Chemical and Screening Sciences, Wyeth Research, 500 Arcola Road, Collegeville, PA 19426, Fax: 484-865-9399, (2) Chemical and Screening Sciences, Wyeth Research, Pearl River, NY 10965, (3) Women's Health and Musculoskeletal Biology, Wyeth Research, Collegeville, PA 19426, (4) Women's Health & Musculoskeletal Biology, Wyeth Research, Cambridge, MA 02140 Activation of the canonical Wnt signaling pathway has been shown to increase trabecular bone formation by stimulating osteoblast activation and differentiation.