Download e-book for iPad: Animal Models of Ophthalmic Diseases by Chi-Chao Chan

By Chi-Chao Chan

This ebook describes experimental animal versions that mimic universal human ocular ailments: herpetic keratitis, cataract, glaucoma, age-related macular degeneration, diabetic retinopathy, uveitis, retinitis pigmentosa, Graves’ sickness, and intraocular tumors. In conjunction, those types mirror the range and software of instruments used to review human ailment. international specialist clinicians talk about each one version in line with their medical adventure and the textual content is supported through a number of photographs and diagrams. In describing the main pertinent animal types of ophthalmic illnesses, this ebook could be of curiosity to ophthalmologists, imaginative and prescient researchers, fellows, citizens and clinical students.

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2006a; DeRosa et al. 2007; DeRosa et al. 2009; Berthoud and Beyer 2009; Xia et al. 2012; Rubinos et al. 2014). 3 Cytoskeletal and Membrane Proteins Major intrinsic protein (MIP), also known as aquaporin 0, is a voltage-dependent water channel and the most abundant membrane-associated protein in lens fiber cells (Bloemendal et al. 1972; Gorin et al. 1984). Models of disruption in the mouse gene Mip determine that the cataractous phenotype of Mip mutant mice is due to disruption in the fiber cell differentiation, and subsequent disruption protein solubility in the crystallin lens (Shiels and Bassnett 1996; Sidjanin et al.

Am J Ophthalmol 78:972–984 Galichanin K, Lofgren S, Bergmanson J, Soderberg P (2010) Evolution of damage in the lens after in vivo close to threshold exposure to UV-B radiation: cytomorphological study of apoptosis. Exp Eye Res 91(3):369–377. 009 Garner WH, Garner MH, Spector A (1981) Gammacrystallin, a major cytoplasmic polypeptide disulfide linked to membrane proteins in human cataract. , Sinha D (2006) Developmental abnormalities in the Nuc1 rat retina: a spontaneous mutation that affects neuronal and vascular remodeling and retinal function.

2012a). The albino Sprague–Dawley rat has also been a common model over the years with an extensive database on UVB-induced cataract J. West-Mays and S. Bowman ­(Galichanin et al. 2010; Soderberg 1990; Soderberg et al. 2002; Wang et al. 2010). Much of these data, along with other species, have revealed important mechanisms underlying UVR-induced cataract, particularly for UVB and the development of cortical cataract. For example, UVB can cause direct DNA damage and generate ROS, singlet oxygen, superoxide, hydrogen peroxide, and hydroxyl radicals leading to oxidative stress and apoptosis of LECs (Michael et al.

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